Gene description for RAPGEF2
Gene name Rap guanine nucleotide exchange factor 2
Gene symbol RAPGEF2
Other names/aliases PDZ-GEF1
RA-GEF-1
nRap GEP
Species Bos taurus
 Experiment description of studies that identified RAPGEF2 in Bovine milk

1
Experiment ID439
Identified moleculeprotein
Extracellular vesicle typeExosomes/Membrane vesicles
MISEVEVs
Identification method Mass spectrometry
PubMed ID 22129587   
OrganismBos taurus
Experiment descriptionBovine milk exosome proteome.
AuthorsReinhardt TA, Lippolis JD, Nonnecke BJ, Sacco RE.
Journal name J Proteomics
Publication year2012
SampleBovine milk
Sample nameNormal cow-Milk
Isolation/purification methods-
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK EV120041: EV-METRIC:56%

2
Experiment ID503
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Mass spectrometry
PubMed ID 23459212   
OrganismBos taurus
Experiment descriptionBovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
AuthorsReinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year2013
SampleBovine milk
Sample nameStaphylococcus aureus-infected-Milk
Isolation/purification methods-
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK EV130111: EV-METRIC:43%

3
Experiment ID1047
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Mass spectrometry
PubMed ID 28725021   
OrganismBos taurus
Experiment descriptionBovine milk-derived exosomes from colostrum are enriched with proteins implicated in immune response and growth.
AuthorsSamuel M, Chisanga D, Liem M, Keerthikumar S, Anand S, Ang CS, Adda CG, Versteegen E, Jois M, Mathivanan S.
Journal name Sci Rep.
Publication year2017
SampleBovine milk
Sample nameBovine milk - colostrum 48 h
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Density gradient centrifugation
Flotation density1.08.1.24 g/mL
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
Western blotting
EV-TRACK -

4
Experiment ID1048
Identified moleculeprotein
Extracellular vesicle typeExosomes
MISEVEVs
Identification method Mass spectrometry
PubMed ID 28725021   
OrganismBos taurus
Experiment descriptionBovine milk-derived exosomes from colostrum are enriched with proteins implicated in immune response and growth.
AuthorsSamuel M, Chisanga D, Liem M, Keerthikumar S, Anand S, Ang CS, Adda CG, Versteegen E, Jois M, Mathivanan S.
Journal name Sci Rep.
Publication year2017
SampleBovine milk
Sample nameBovine milk - mature milk
Isolation/purification methodsDifferential centrifugation
Ultracentrifugation
Density gradient centrifugation
Flotation density1.08.1.24 g/mL
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
Western blotting
EV-TRACK -

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